2018英特爾ISEF學科最佳作品摘要：生物化學 | Best of Category Abstract: Biochemistry

獲獎作品基本信息

年份	2018
學科	生物化學 Biochemistry
學校	Moravian Academy
國家/州	PA，United States of America

獲獎作品名稱

The Biochemical Interactions of Cardiac Ion-Blocking Agents and Optical Coherence Tomography in vivo for Cardiovascular Diseases

獲獎作品摘要

Optical Coherence Tomography (OCT) is a novel 3D-imaging modality, however there has been limited research utilizing OCT to study physiological impacts of ion-blocking drugs, namely Class I, III, and IV antiarrhythmics. An OCT drosophila model was developed for live non-invasive analysis of cardiovascular disease and pharmaceutical testing. With extensive drug delivery protocol optimization, Ca????, K??, and Na?? channel blockers were dissolved into sugar based food at 0.1% and 0.01% of standard human dosage, Amlodipine Besylate, Dofetilide, and Flecainide Acetate, respectively.
108 samples’ heart rate and area were processed through a Segmentation and Python algorithms at Instar Stage III and adult. Ultimately, Amlodipine suppressed chronotropy while proarrhythmic characteristics were surprisingly observed in Dofetilide and Flecainide treated samples, signaling potential cardiotoxicity.
Combining chemical therapeutics with bio-optics yields novel implications for potential of optogenetics in cardiotherapy for major chronic heart diseases with 3-dimensional live graphics and enhances understanding of the antiarrythmic biochemical agents currently used to treat them.
The drosophila optical model is an effective way to analyze the chronotropic properties of antiarrythmics to easily test the biomechanical effects of drugs before experimenting on mammalian species or human populations. This reduces the cost and time of developing drugs by quickly identifying experimental molecules with cardiotoxic effects, enhancing general physiological understanding of the drugs to begin with.

 

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ISEF 簡介

英特爾國際科學與工程大獎賽，簡稱 "ISEF"，由美國 Society for Science and the Public（科學和公共服務協會）主辦，英特爾公司冠名贊助，是全球規模最大、等級最高的中學生的科研科創賽事。ISEF 的學術活動學科包括了所有數學、自然科學、工程的全部領域和部分社會科學。ISEF 素有全球青少年科學學術活動的“世界杯”之美譽，旨在鼓勵學生團隊協作，開拓創新，長期專一深入地研究自己感興趣的課題。

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英特爾 ISEF 學術活動詳細介紹

英特爾 ISEF 全程指導方案

· 數學 · 物理 · 化學 · 生物 · 計算機 · 工程 ·

學科簡介：生物化學 Biochemistry

The study of the chemical basis of processes occurring in living organisms, including the processes by which these substances enter into, or are formed in, the organisms and react with each other and the environment.

Subcategories:

Analytical Biochemistry?(ANB):?The study of biochemical components found in a cell or other biological sample.?The study of the separation, identification, and quantification of chemical components relevant to living organisms.

General Biochemistry?(GNR):?The study of chemical and physiochemical?processes, including interactions and reactions, relevant to living organisms.

Medicinal Biochemistry?(MED):?The study of biochemical processes within the human body, with special reference to health and disease.

Structural Biochemistry?(STR):?The study of components, functions, and structures of molecules of cells within living organisms. Projects in this subcategory can address various variables of cells through the theories of Chemistry and the laws of Physics.

Other?(OTH):?Studies that cannot be assigned to one of the above subcategories. If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.