Mammalian heart structure

• The heart is a hollow,?muscular organ?located in the chest cavity
• The heart is divided into?four chambers
  • The two top chambers are?atria
  • The bottom two chambers are?ventricles
• The left and right sides of the heart are separated by a wall of muscular tissue called the?septum.
  • The septum is very important for ensuring blood doesn’t mix between the left and right sides of the heart
• Valves?are important for keeping blood flowing?forward?in the right direction and stopping it flowing backwards. They are also important for maintaining the correct pressure in the chambers of the heart
  • The atria and ventricles are separated by the?atrioventricular valves
  • The ventricles and the arteries that leave the heart are separated by?semi-lunar valves
    • The right ventricle and the pulmonary artery are separated by the?pulmonary valve
    • The left ventricle and aorta are separated by the?aortic valve
• There are two blood vessels bringing blood to the heart; the?vena cava?and?pulmonary vein
• There are two blood vessels taking blood away from the heart; the?pulmonary artery?and?aorta

The human heart has four chambers and is separated into two halves by the septum

Contraction of the heart muscle

• The contraction of the heart is called?systole, while the relaxation of the heart is called?diastole
• Atrial systole?is the period when the atria are contracting and?ventricular systole?is when the ventricles are contracting
• Atrial systole happens around 0.13 seconds after ventricular systole
• Atrial systole forces blood?from the atria into the ventricles
• During ventricular systole, blood is forced?from the ventricles into the?pulmonary artery?and?aorta
• One systole and diastole makes a heartbeat and lasts around 0.8 seconds in humans.
• This is the?cardiac cycle

Initiation of the heartbeat by the sinoatrial node

• The heart muscle is?myogenic, meaning that the heart will beat without any external stimulus from other organs or the nervous system
  • This intrinsic control causes the heart to beat at around 60 beats per minute
• The heart beat is initiated by a?group of cells?in the wall of the?right atrium?called the?sinoatrial node?(SAN)
• The cells of the sinoatrial node?depolarise, reversing the charge across their membranes
  • This triggers a?wave of depolarisation?that spreads across the rest of the heart
• The sinoatrial node is considered to be the?pacemaker?of the heart because it?initiates?the heart beat and so controls the?speed at which the heart beats
  • Note that?artificial pacemakers?are electronic devices implanted just underneath the skin. They can be used to replace or regulate the sinoatrial node if it becomes defective

Electrical control of the cardiac cycle

• The?cardiac cycle?is the series of events that take place in?one heart beat, including?atrial?and?ventricular systole
• The cardiac cycle is controlled by?electrical signals?that are initiated in the?sinoatrial node
  • Depolarisation of the cells in the?sinoatrial node?sends an electrical signal over the?atria, causing them to contract in?atrial systole
  • The electrical signal then reaches a region of?non-conducting?tissue which prevents it from spreading straight to the ventricles; this causes the signal to pause for around 0.1 s
    • This delay means that the atria can?complete their contraction?before the ventricles begin to contract
  • The electrical signal is carried to the ventricles via the?atrioventricular node?(AVN)
    • This is a region of conducting tissue between atria and ventricles
  • The signal then travels to the base of the heart via?conductive fibres?in the septum known as the bundle of His
  • The electrical signal is then carried through another set of conductive fibres called Purkyne fibres which spread around the sides of the ventricles, causing?contraction of the ventricles?from the apex, or base, of the heart upwards
    • This is called?ventricular systole
    • Blood is forced out of the heart into the?pulmonary artery?and?aorta

Electrical Control of the Cardiac Cycle Table

The wave of depolarisation spreads across the heart in a coordinated manner

The cells of the sinoatrial node depolarise and send out an electrical signal which spreads across both atria, causing atrial systole. Non-conducting tissue between the atria and ventricles prevents depolarisation from spreading to the ventricles, ensuring that the atria finish contracting before the ventricles begin. The atrioventricular node then sends the electrical signal to the apex of the ventricles via conductive fibres in the septum known as the bundle of His. The electrical signal is then carried upwards around the walls of the ventricles by conductive tissues called Purkyne fibres. This means that during ventricular systole, the blood contracts from its base and blood is pushed upwards and outwards.

• Contraction?of the heart muscle causes an?increase in pressure?in the corresponding chamber if the heart, which then?decreases?again when the muscle?relaxes
• Throughout the cardiac cycle,?heart valves open and close?as a result of?pressure changes?in different regions of the heart:
  • Valves?open?when the pressure of blood?behind them is greater than the pressure in front of them
  • They?close?when the pressure of blood?in front of them is greater than the pressure behind them
• Valves are an important mechanism?to stop blood flowing backwards
• The pressure changes of the cardiac cycle can be represented in a graph

Pressure changes during diastole

• During?diastole, the heart muscle is?relaxing
  • During this period, blood begins to flow into the atria from the veins,?increasing the atrial pressure
• Relaxed muscle in the heart walls?recoils,?increasing the volume?of the chambers of the heart:
  • The?atrioventricular valves open?as the pressure in the atria is higher than the pressure in the ventricles
  • The?semilunar valves close?as the pressure in the pulmonary artery and aorta is higher than the pressure in the ventricles

Pressure changes during systole

• During?systole, the heart?contracts?and pushes blood out of the heart
• The?contraction of the muscles?in the wall of the heart?reduces the volume?of the heart chambers and?increases the pressure?within that chamber
• In?atrial systole, the atria contract
  • The?atrioventricular valves are open?as the pressure in the atria exceeds the pressure in the ventricles
  • The?semilunar valves are?closed?as the pressure in the ventricles is less than the pressure in the aorta and pulmonary artery
• In?ventricular systole, the ventricles contract
  • • The?atrioventricular valves are closed?as the pressure in the ventricles exceeds the pressure in the atria
    • The?semilunar valves are?open?as the pressure in the ventricles exceeds the pressure in the aorta and pulmonary artery

Graph showing the pressure changes within the aorta, left atrium and left ventricle during the cardiac cycle. The atrioventricular valves open at E and close at B, while the semilunar valves open at C and close at D.

Analysing the cardiac cycle

• The lines on the graph represent the?pressure?of the left atrium, aorta, and the left ventricle
• The points at which the?lines cross each other?are important because they indicate when?valves open and close

Point A - the end of diastole

• The atrium has filled with blood during the preceding diastole
• Pressure is higher in the atrium than in the ventricle, so the?AV valve is open

Between points A and B - atrial systole

• Left atrium contracts,?causing an increase in atrial pressure and forcing blood into the left ventricle
• Ventricular pressure increases slightly as it fills with blood
• Pressure is higher in the atrium than in the ventricle, so the?AV valve is open

Point B - beginning of ventricular systole

• Left ventricle contracts?causing the ventricular pressure to increase
• Pressure in the left atrium drops as the muscle relaxes
• Pressure in the ventricle exceeds pressure in the atrium, so the?AV valve shuts

Point C - ventricular systole

• The ventricle continues to contract
• Pressure in the left ventricle exceeds that in the aorta
• Aortic valve opens?and blood is forced into the aorta

Point D - beginning of diastole

• Left ventricle has been emptied of blood
• Muscles in the walls of the left ventricle relax and pressure falls below that in the newly filled aorta
• Aortic valve closes

Between points D and E - early diastole

• The ventricle?remains relaxed?and ventricular pressure continues to decrease
• In the meantime, blood is?flowing into the relaxed atrium?from the pulmonary vein, causing an increase in pressure

Point E - diastole

• The relaxed left atrium fills with blood, causing the pressure in the atrium to exceed that in the newly emptied ventricle
• AV valve opens

After point E - late diastole

• There is a short period of time during which the?left ventricle expands?due to relaxing muscles
• This increases the internal volume of the left ventricle and?decreases the ventricular pressure
• At the same time, blood is flowing slowly through the newly opened AV valve into the left ventricle, causing a?brief decrease in pressure?in the left atrium
• The pressure in both the atrium and ventricle then?increases slowly?as they continue to fill with blood