• Charles Darwin proposed the?theory of evolution by natural selection
  • He came up with this theory as a result of observations from a round-the-world expedition, years of experimentation and his knowledge of geology and fossils

   

• Evolution can be defined as?the change in the frequency of a phenotype in a population over many generations
• Darwin’s theory, very simply, is:
  • Individuals in a species show a wide?range of variation?caused by differences in genes
  • Individuals with characteristics?most suited to the environment?have a higher chance of survival and?more chances to reproduce
  • Therefore these characteristics are?passed to their offspring at a higher rate?than those with characteristics less suited to survival
  • Over many generations, these?beneficial characteristics?become?more common in the population?and the species changes (the species evolves)

   

• This idea of natural selection became known as?‘survival of the fittest’
• Darwin published his ideas in his famous book,?On the Origin of Species?(1859)

The acceptance of evolution

• The theory of evolution by natural selection was only gradually accepted because:
  • There was much controversy surrounding these?revolutionary new ideas
  • The theory?challenged the idea that God made all the animals and plants?that live on Earth
  • There was?insufficient evidence?at the time the theory was published to convince many scientists
  • The?mechanism of inheritance and variation was not known?until 50 years after the theory was published
  • The theory of evolution by natural selection?developed over time?and from information gathered by many scientists

   

Examples of evolution by natural selection

Natural selection illustrated by snail shell colour

Another good example of natural selection is the evolution of the peppered moths

• Antibiotics are?chemical substances?made by certain?fungi or bacteria?that affect the working of bacterial cells, either by?disrupting their structure or function?or by?preventing them from reproducing
• Antibiotics are?effective against bacteria but not against viruses
• Antibiotics target processes and structures that are specific to bacterial (prokaryotic) cells; as such they do not generally harm animal cells

How antibiotics work

• The use of antibiotics has increased exponentially since they were first introduced in the 1930s
• In that time they have saved millions of lives

The introduction of antibiotics has had one of the largest impacts on global health, shown by this example in the USA

• However, since their discovery and widespread use, antibiotics have been?overused?and?antibiotic?resistance?has developed in many different types of bacterial species
  • Bacteria, like all organisms, have?random?mutations?in their DNA
  • One of these mutations may give them resistance to an antibiotic
  • If an organism is infected with bacteria and some of them have resistance, they are likely to survive treatment with antibiotics
  • The population of the resistant bacteria will increase
  • If the resistant strain is causing a serious infection then another antibiotic will be needed
  • A strain of?Staphylococcus aureus?has developed resistance to a powerful antibiotic methicillin, this is known as MRSA (Methicillin resistant?Staphylococcus aureus)
  • MRSA can infect wounds and is difficult to treat without antibiotics

   

Bacteria evolve rapidly as they reproduce quickly and acquire random mutations – some of which confer resistance

Preventing resistant bacteria

• To reduce the number of bacteria that are becoming resistant to antibiotics:
  • Doctors need to avoid the overuse of antibiotics, prescribing them only when needed – they may test the bacteria first to make sure that they prescribe the correct antibiotic
  • Antibiotics shouldn't be used in non-serious infections that the immune system will ‘clear up’
  • Antibiotics shouldn't be used for viral infections
  • Patients need to finish the whole course of antibiotics so that all the bacteria are killed and none are left to mutate to resistant strains
  • Antibiotics use should be reduced in industries such as agriculture – controls are now in place to limit their use in farming

   

Reducing the spread of resistant strains

• Good hygiene practices such as handwashing and the use of hand sanitisers have reduced the rates of resistant strains of bacteria, such as?MRSA,?in hospitals
• The isolation of infected patients to prevent the spread of resistant strains, in particular in surgical wards where MRSA can infect surgical wounds

Antibiotics do not affect viruses

• Viruses cannot be treated with antibiotics
• This is because antibiotics work by?disrupting cell functions such as respiration, or breaking down the structure of the cell in some way
• However, viruses?do not carry out any cell functions?and?do not have cell walls, cell membranes or any cell organelles?as viruses infect and utilise the machinery of animal cells to reproduce, which are not affected by antibiotics.
• Therefore the action of antibiotics?do not affect them

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