2018英特爾ISEF學科最佳作品摘要：細胞與分子生物學 | Best of Category Abstract: CELLULAR AND MOLECULAR BIOLOGY

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獲獎作品基本信息

年份	2018
學科	細胞與分子生物學 CELLULAR AND MOLECULAR BIOLOGY
學校	Horace Mann School
國家/州	NY，United States of America

獲獎作品名稱

Exploring Posterior Growth in D. rerio Using a Live Cell Cycle Biosensor

獲獎作品摘要

Though cell cycle regulation plays a key role in numerous developmental processes, including morphogenesis and differentiation, the regulatory systems that control the cell cycle remain poorly understood. Surprisingly, past studies have shown a correlation between invasive behavior and G1 cell cycle arrest. To explore this relationship, a cell cycle state biosensor has been adapted for use in zebrafish. The sensor provides a visual readout of cell cycle state based on the localization of DNA Helicase B (DHB), which is determined by cyclin-dependent kinase 2 (CDK2) activity. The sensor was validated by comparing it with Fluorescence Ubiquitin Cell Cycle Indicator (Fucci) and characterized it by inducing G1/S phase cell cycle arrest through treatment with Palbociclib and hydroxyurea. The effects of cell cycle dysregulation on tailbud development were also explored. Overexpression of CDKN1A/p21, a cyclin- dependent kinase inhibitor, was found to induce G1 cell cycle arrest in tailbud cells and disrupt development by forcing additional cells to invade into the notochord. Our sensor provides new evidence for the hypothesis that G1 cell cycle arrest induces invasive behavior and lays the foundation for understanding the relationship between cell cycle regulation and invasion, a concept that is critical to our understanding of cancer metastasis.

 

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高中生科研 英特爾 Intel ISEF
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ISEF 簡介

英特爾國際科學與工程大獎賽，簡稱 "ISEF"，由美國 Society for Science and the Public（科學和公共服務協會）主辦，英特爾公司冠名贊助，是全球規模最大、等級最高的中學生的科研科創賽事。ISEF 的學術活動學科包括了所有數學、自然科學、工程的全部領域和部分社會科學。ISEF 素有全球青少年科學學術活動的“世界杯”之美譽，旨在鼓勵學生團隊協作，開拓創新，長期專一深入地研究自己感興趣的課題。

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英特爾 ISEF 學術活動詳細介紹

英特爾 ISEF 全程指導方案

· 數學 · 物理 · 化學 · 生物 · 計算機 · 工程 ·

學科簡介：細胞與分子生物學 CELLULAR AND MOLECULAR BIOLOGY

This is an interdisciplinary field that studies the structure, function, intracellular pathways, and formation of cells. Studies involve understanding life and cellular processes specifically at the molecular level.

Subcategories:

Cell Physiology?(PHY):?The study of the cell cycle, cell function, and interactions between cells or between cells and their environment.?In general, projects could address physiology of membrane transport, neuron transmission, muscle contraction, the digestion of food, circulation of blood, contraction of muscles, or movement and production of nutrients in plant cells.In general, projects could address physiology of membrane transport, neuron transmission, muscle contraction, the digestion of food, circulation of blood, contraction of muscles, or movement and production of nutrients in plant cells.

Cellular Immunology?(IMM):?The study of the structure and function of the immune system at the cellular level.?This includes investigations of innate and acquired (adaptive) immunity, the cellular communication pathways involved in immunity, cellular recognition and interactions between antigens and antibodies.

Genetics?(GEN):?The study of molecular genetics focusing on the structure and function of genes at a molecular level.genes, genetic variation, and heredity in living cells. These projects explore the consequences of genome variation on human cell biology, and thus gene function in health and disease. ?Furthermore, projects may study the impact of naturally-occurring and engineered genome mutations in human iPS cells, their differentiated derivatives, and other cell types.

Molecular Biology?(MOL):?The study of biology at the molecular level. Chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interrelationships of DNA, RNA and protein synthesis and learning how these interactions are regulated, such as during transcription and translation, the significance of introns and exons or coding issues.

Neurobiology?(NEU):?The study of the structure and function of the nervous system at the cellular or molecular level.?This area focuses on the study of cells of the nervous system and the organization of these cells into functional circuits that process information and mediate behavior. Some neurobiology focuses on the molecular structures of the brain and nervous system. Larger complete systems, like the function and structure of the cerebral cortex, may be studied. Projects can look at biological factors that impact learning or mood, or how early genetic material develops into various areas of the brain.

OTH?Other?(OTH):?Studies that cannot be assigned to one of the above subcategories. If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.
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