• A large number of organic products are made from a few starting compounds using appropriate reagents and conditions
• Knowing how organic functional groups are related to each other is key to the synthesis of a given molecule
• The main functional groups you need to know are
  • Alkanes
  • Alkenes
  • Haloalkanes
  • Nitriles
  • Amines
  • Alcohols
  • Carbonyls (aldehydes & ketones)
  • Hydroxynitriles
  • Carboxylic acids
  • Esters
  • Acyl chlorides
  • Primary and secondary amides

Aliphatic Reaction Pathways

• The key interconversions between functional groups are summarised here:

Aliphatic Reactions Table

Aromatic Reaction Pathways

• The key aromatic reactions are summarised here:

Aromatic Reactions Table

Designing a Reaction Pathway

• The given molecule is usually called the?target molecule?and chemists try to design a synthesis as efficiently as possible
• Designing a reaction pathway starts by drawing the structures of the?target molecule?and the?starting molecule
• Determine if they have the?same number?of carbon atoms
  • If you need to lengthen the carbon chain you will need to put on a?nitrile group?by nucleophilic substitution

   

• Work out all the compounds that can be made from the starting molecule and all the molecules that can be made into the target molecule
  • Match the groups they have in common and work out the reagents and conditions needed

   

Answer 1

Answer 2