• During early development an embryo develops?embryonic?gonads?that will either become?ovaries?in females or?testes?in males
• The factor that determines whether the embryonic gonads will develop into ovaries or testes is the?presence or absence?of a?single?gene?known as the?SRY gene
• The SRY gene is on the?Y chromosome,?so if the embryo has?two X chromosomes?the embryonic gonads?will develop into?ovaries
• This means?testosterone?will not be secreted by the developing embryo
• The two female hormones?oestrogen?and?progesterone?are?present throughout pregnancy
  • These hormones are secreted by the?mother's ovaries?and the?placenta
• The absence of foetal testosterone and presence of maternal oestrogen and progesterone causes female reproductive organs to develop
• During female?puberty,?oestrogen and progesterone secretions increase.
• This leads to:
  • The start of the?menstrual cycle
  • The development of female?secondary sexual characteristics e.g. breast development

Secondary sexual characteristics of a human female

• The?menstrual cycle?is the series of changes that take place in the female body leading up to and following the release of an egg from the ovaries
  • It starts in early adolescence in girls and is controlled by?hormones
  • The average menstrual cycle is?28 days?long
• The?uterus lining, or?endometrium, thickens from?day 7?through to?day 28?of the cycle in preparation for receiving a?fertilised?egg
• The release of an egg, or?ovulation, occurs about?halfway?through the cycle?on?day?14,?and the egg then travels down the oviduct to the uterus
  • Eggs develop inside fluid-filled sacs known as?egg follicles?inside the ovary
  • The follicle releases the egg at ovulation and becomes an empty follicle known as a?corpus luteum
• Failure to fertilise the egg leads to?menstruation,?commonly known as a period
  • Menstruation involves the loss of menstrual blood via the vagina
  • This is caused by the?breakdown of?the endometrium
• Menstruation takes place roughly between?days 1-7?of the cycle
  • The number of days during which menstruation occurs can vary
• After menstruation finishes, the endometrium starts to?thicken again?in preparation for the?possible implantation of a fertilised egg in the next cycle

Changes in the endometrium during the menstrual cycle

How ovarian and pituitary hormones control the menstrual cycle

• Four?hormones?control the events that occur during the menstrual cycle:
  • Two of these hormones are produced by the?pituitary gland?in the brain
    • Follicle-stimulating?hormone (FSH)
    • Luteinising?hormone (LH)
  • The other two hormones are produced in the?ovaries
    • Oestrogen;?produced by the?egg follicle,?and by the?corpus luteum?after ovulation
    • Progesterone;?produced by the corpus luteum
• The roles of FSH and LH:
  • FSH is secreted by the?pituitary gland?and stimulates the?development?of several immature?egg cells?in?follicles?in the?ovary
  • FSH also stimulates the?secretion of?oestrogen?by the?follicle wall
  • The?pituitary gland?is stimulated to release LH when?oestrogen?levels have reached their?peak
  • LH causes?ovulation to occur;?the shedding of the mature egg cell from the follicle and its release from the ovary
    • The shedding of the mature egg cell leaves behind an empty egg follicle called the corpus luteum
  • LH also?stimulates?the production of?progesterone from the corpus luteum

Changes in the levels of the pituitary hormones FSH and LH in the blood during the menstrual cycle

• The roles of oestrogen and progesterone:
  • Oestrogen?levels rise from?day 1?to?peak?just before?day 14
  • This causes the?endometrium?to start?thickening?and the egg cell to?mature
  • The peak in oestrogen occurs just before the egg is released
  • Progesterone?stays low from day 1-14 and starts to rise once ovulation has occurred
    • Progesterone is produced by the corpus luteum
  • The increasing levels of progesterone cause the endometrium to continue to thicken
  • A fall in progesterone levels as the corpus luteum deteriorates causes the endometrium to?break down, resulting in?menstruation

Changes in the levels of oestrogen and progesterone in the blood during the menstrual cycle

Negative and positive feedback mechanisms controlling the menstrual cycle

• The four hormones all?interact?to control the menstrual cycle via both?negative?and?positive feedback
  • FSH and oestrogen
    • FSH stimulates the development of a follicle, and the follicle wall produces the hormone oestrogen; it can be said that?FSH stimulates the production of oestrogen
    • As well as causing growth and repair of the endometrium, oestrogen also causes an?increase in FSH receptors;?this makes the follicles?more receptive to FSH?which, in turn,?stimulates more oestrogen production
      • This is?positive feedback
    • When oestrogen levels are high enough, it?inhibits the secretion of FSH
      • This is?negative feedback
  • LH and oestrogen
    • When oestrogen rises to a high enough level, it?stimulates the release of LH?from the pituitary gland, causing ovulation on around day 14 of the cycle
    • After ovulation,?LH causes the wall of the follicle to develop into the corpus luteum,?which?secretes more oestrogen
      • This is?positive feedback?
  • LH and progesterone
    • LH?stimulates the wall of the follicle to develop into the?corpus luteum,?which?secretes progesterone
    • Progesterone thickens and maintains the endometrium but also?inhibits the secretion of FSH and LH?from the pituitary gland
      • This is?negative feedback

Where hormones involved in the menstrual cycle are made and act - remember that hormones travel around the body in the bloodstream but only have an effect on a target organ

• A couple may find it difficult to conceive a baby?naturally
• This can be due to?insufficient levels of reproductive hormones?affecting the development of egg and sperm cells, or as a result of?issues with the reproductive system of the male or female
• One possible treatment is for eggs to be fertilised by sperm?outside the body?in carefully controlled laboratory conditions
  • This is known as?in?vitro?fertilisation, or?IVF
• Although the process can vary, it normally follows the same main steps:
  • The first step involves stopping the normal secretion of hormones; the woman takes a drug to?inhibit the secretion of FSH and LH?from the pituitary gland
    • This also causes oestrogen and progesterone secretions to stop
  • This?temporarily halts the menstrual cycle, allowing doctors to?control the?timing?and?quantity?of?egg production?in the woman's ovaries
  • The woman is then given?injections of FSH and LH to stimulate the development of follicles;?as the injection gives a much higher FSH concentration than is present during a normal menstrual cycle, 'superovulation' occurs
    • Many more follicles than normal begin to mature
  • The eggs are then collected from the woman and fertilised by sperm from the man in?sterile conditions in the laboratory
  • The fertilised eggs develop into?embryos
  • At the stage when they are tiny balls of cells, about?48 hours after fertilisation, one or more embryos are inserted into the mother’s uterus
  • Finally,?extra progesterone?is normally given to the woman to ensure the?endometrium?is?maintained
• The success rate of IVF is low (~30%) but there have been many improvements and advancements in medical technologies which are helping to increase the success rate