2019英特爾ISEF學科最佳作品摘要：生物醫學與健康科學 | Best of Category Abstract: BIOMEDICAL AND HEALTH SCIENCES
獲獎作品基本信息
| 年份 | 2019 |
| 學科 | 生物醫學與健康科學 BIOMEDICAL AND HEALTH SCIENCES |
| 國家/州 | MI，United States of America |
獲獎作品名稱
A Novel, Noninvasive Approach to Melanoma Diagnosis Using Optical Coherence Tomography and Bioconjugated Gold Nanoparticles
獲獎作品摘要
Melanoma is the deadliest skin cancer with over 9,000 deaths per year, but melanoma detected early results in over 90% chance of cure. Currently, a biopsy is the most common method of melanoma diagnosis, but it can take up to two weeks to receive results, cost hundreds of dollars, and is invasive and traumatizing to the patient. Thus, there is an unmet clinical need for noninvasive, quick, and inexpensive diagnosis of melanoma. Optical Coherence Tomography (OCT) is a relatively new non-invasive imaging modality which is cost-effective and portable. However, without contrast agents, OCT’s use in biological imaging is limited. My project developed a new contrast agent to noninvasively diagnose suspicious melanoma lesions and tested various concentrations and sizes to determine the ideal parameters for this contrast agent. I conducted an in-vitro study of OCT signal where I demonstrated that my novel contrast agent, gold nanospheres conjugated with Galectin-3 protein antibodies as a biomarker, binds significantly greater to melanoma than to fibroblast cell lines. The resulting dramatic signal difference enables a melanoma diagnosis. OCT signal contrast peaked at nanoparticle sizes of 5nm and 10nm, while 10nm and 50nm displayed relatively low toxicity based on light microscope images to compare cell death. My study has laid the groundwork for the use of this novel contrast agent and OCT technology in the early detection of melanoma in a clinical setting. By using this noninvasive diagnostic technique, up to 60% of suspicious cases will be spared a biopsy. Ultimately, this approach represents a new paradigm whereby noninvasive screening yields a greater incidence of early, cost-effective skin cancer diagnosis, saving thousands of lives globally.
高中生科研 英特爾 Intel ISEF
資訊 · 課程 · 全程指導
請掃碼添加微信好友
[vc_btn title="聯系電話：(021) 63526628" color="black" align="center" css_animation="fadeIn" link="url:tel%3A02163526628||target:%20_blank|rel:nofollow"]
ISEF 簡介
英特爾國際科學與工程大獎賽，簡稱 "ISEF"，由美國 Society for Science and the Public（科學和公共服務協會）主辦，英特爾公司冠名贊助，是全球規模最大、等級最高的中學生的科研科創賽事。ISEF 的學術活動學科包括了所有數學、自然科學、工程的全部領域和部分社會科學。ISEF 素有全球青少年科學學術活動的“世界杯”之美譽，旨在鼓勵學生團隊協作，開拓創新，長期專一深入地研究自己感興趣的課題。
>>> 實用鏈接匯總 <<<
- 數學 - 物理 - 化學 - 生物 - 計算機 - 工程 -
學科簡介：生物醫學與健康科學 BIOMEDICAL AND HEALTH SCIENCES
This category focuses on studies specifically designed to address issues of human health and disease. It includes studies on the diagnosis, treatment, prevention or epidemiology of disease and other damage to the human body or mental systems. Includes studies of normal functioning and may investigate internal as well as external factors such as feedback mechanisms, stress or environmental impact on human health and disease.
Subcategories:
Cell, Organ, and Systems Physiology?(PHY):?These studies investigate mechanisms that are involved in maintaining health or when disrupted, cause disease. They could involve investigating such things as the role of cell signaling pathways both within the cell (intracellular) and/or between cells (extracellular). Alternatively, studies in this subcategory could investigate the maintenance of homeostasis at the organ or whole body level (e.g., hormonal control and regulation). These studies may also be in areas such as disease-related, stress-related, biochemical, mechanical, or physical changes at the tissue, organ, and /or cellular level.
Genetics and Molecular Biology of Disease?(GEN):?These studies investigate the genetic and molecular mechanisms involved in the regulatory pathways that maintain normal body and cellular function or if disturbed can lead to disease. Studies could include examining the activation and deactivation of genes (e.g., transcription factors or epigenetic regulation) or involve more classical genetic identification studies.
Immunology?(IMM):?These studies will investigate any aspects of the immune system that are involved in maintaining health or when altered lead to pathology. These studies can include new investigations of normal immune function (e.g., immune cell interactions and signaling), or they may study diseases caused by disorders in regulation of the immune system (e.g., immunodeficiency or autoimmunity). Alternatively the studies could investigate problems such as graft vs host or host versus graft disease that arise during the treatment of other diseases or conditions.
Nutrition and Natural Products?(NTR):?The study of food, nutrients and dietary need in humans, and the effects of food and nourishment on the body. ?These studies may include the effects of natural or supplemental nutrients and nutrition.
Pathophysiology?(PAT):?These studies will be focused on determining specific causes of disease and on physiological mechanisms responsible for disease development. Investigations in this category will examine changes in the normal physiological balance, or homeostasis that cause a reaction(s) within the body leading to disease.
Other?(OTH):?Studies that cannot be assigned to one of the above subcategories.?If the project involves multiple subcategories, the principal subcategory should be chosen instead of Other.
翰林AMC8視頻課重磅上線！
國際競賽真題資源免費領取
